[应用cDNA芯片技术检测肺癌组织中MMP1和TIMP1的基因表达]。

Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University Pub Date : 2003-06-01

Qu-chang Ouyang, Cheng-ping Hu, Qing-hua Liang

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引用次数: 0

摘要

目的:探讨基质金属蛋白酶1(MMP1)基因表达及基质金属蛋白酶1组织抑制剂(TIMP1)在肺鳞状细胞癌和腺癌中的表达。方法:采用基因表达谱cDNA微阵列技术鉴定肺癌鳞状细胞癌和腺癌中差异表达基因，分析MMP1和TIMP1基因表达情况。结果:MMP1和TIMP1基因在肺鳞状细胞癌和腺癌中均有差异表达，且均上调表达。结论:MMP1和TIMP1可能是肺鳞状细胞癌和腺癌的重要分子标志物。

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[Gene expression of MMP1 and TIMP1 in lung cancer detected with a cDNA microarray technique].

Objective: To investigate the gene expression of matrix metalloproteinases 1 (MMP1) and tissue inhibitors of matrix metalloprotainases 1(TIMP1) in squmas cell lung cancer and adenocarcinoma.

Methods: Gene expression profile cDNA microarray egntaining 4,096 genes was used to identify differentially expressed genes in squmas cell lung cancer and adenocarcinoma, and to analyze the gene expression of MMP1 and TIMP1.

Results: Gene MMP1 and TIMP1 were differentially expressed in both squmas cell lung cancer and adenocarcinoma, and both of them were up-regulated.

Conclusion: MMP1 and TIMP1 may be important molecular markers of squmas cell lung cancer and adenocarcinoma.

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Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University

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