{"title":"全身给予血红素对大鼠肝脏色氨酸吡咯酶活性的影响","authors":"M.V. Jago, J.F. Nelson, S. Rose","doi":"10.1016/0926-6569(64)90267-6","DOIUrl":null,"url":null,"abstract":"<div><p>The saturation with cofactor of the tryptophan pyrrolase of rat liver was markedly increased by intravenous administration of solutions of haematin. Complete saturation followed the administration of 0.5–1 μmole haematin per 100 g body weight or larger amounts. No significant increase in tryptophan pyrrolase activity accompanied or followed this apparent saturation of the enzyme with cofactor <em>in vivo</em>.</p></div>","PeriodicalId":100170,"journal":{"name":"Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects","volume":"92 1","pages":"Pages 44-51"},"PeriodicalIF":0.0000,"publicationDate":"1964-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0926-6569(64)90267-6","citationCount":"7","resultStr":"{\"title\":\"The effect of systemic administration of haematin on the tryptophan pyrrolase activity of rat liver\",\"authors\":\"M.V. Jago, J.F. Nelson, S. Rose\",\"doi\":\"10.1016/0926-6569(64)90267-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The saturation with cofactor of the tryptophan pyrrolase of rat liver was markedly increased by intravenous administration of solutions of haematin. Complete saturation followed the administration of 0.5–1 μmole haematin per 100 g body weight or larger amounts. No significant increase in tryptophan pyrrolase activity accompanied or followed this apparent saturation of the enzyme with cofactor <em>in vivo</em>.</p></div>\",\"PeriodicalId\":100170,\"journal\":{\"name\":\"Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects\",\"volume\":\"92 1\",\"pages\":\"Pages 44-51\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1964-10-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0926-6569(64)90267-6\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0926656964902676\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0926656964902676","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The effect of systemic administration of haematin on the tryptophan pyrrolase activity of rat liver
The saturation with cofactor of the tryptophan pyrrolase of rat liver was markedly increased by intravenous administration of solutions of haematin. Complete saturation followed the administration of 0.5–1 μmole haematin per 100 g body weight or larger amounts. No significant increase in tryptophan pyrrolase activity accompanied or followed this apparent saturation of the enzyme with cofactor in vivo.
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