第二PGD(2)受体CRTH2:在白细胞中的结构、性质和功能。

IF 2.9 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins, leukotrienes, and essential fatty acids Pub Date : 2003-08-01 DOI:10.1016/s0952-3278(03)00078-4

Kinya Nagata, Hiroyuki Hirai

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引用次数: 137

摘要

前列腺素(PG) D(2)具有广泛的生理和病理生理功能。直到几年前，人们还认为PGD(2)的大部分生物学作用是通过经典的PGD(2)受体DP介导的。最近，我们发现了第二种PGD(2)受体，即表达于辅助性T (Th)2细胞(CRTH2)上的趋化受体同源分子，与DP具有不同的功能。本文就该受体的结构、组织分布、配体选择性、信号通路和在白细胞中的功能等方面的最新研究进展进行综述。这些数据表明PGD(2)/CRTH2系统通过刺激Th2细胞、嗜酸性粒细胞和嗜碱性粒细胞在变应性炎症中发挥重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The second PGD(2) receptor CRTH2: structure, properties, and functions in leukocytes.

Prostaglandin (PG) D(2) plays a broad range of physiological and pathophysiological functions. Until just a few years ago, it was thought that most of the biological actions of PGD(2) are mediated via the classical PGD(2) receptor DP. Recently, we identified a second PGD(2) receptor, chemoattractant receptor-homologous molecule expressed on T helper (Th)2 cells (CRTH2), with different functions relative to DP. Here, we review the recent findings on the structure, tissue distribution, ligand selectivity, signalling pathways, and functions in leukocytes of this receptor. The data suggest that the PGD(2)/CRTH2 system play important roles in allergic inflammation through its stimulatory effects on Th2 cells, eosinophils, and basophils.

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来源期刊

Prostaglandins, leukotrienes, and essential fatty acids 医学-内分泌学与代谢

CiteScore

6.40

自引率

6.70%

发文量

审稿时长

13.2 weeks

期刊介绍： The role of lipids, including essential fatty acids and their prostaglandin, leukotriene and other derivatives, is now evident in almost all areas of biomedical science. Cell membrane behaviour and cell signalling in all tissues are highly dependent on the lipid constituents of cells. Prostaglandins, Leukotrienes & Essential Fatty Acids aims to cover all aspects of the roles of lipids in cellular, organ and whole organism function, and places a particular emphasis on human studies. Papers concerning all medical specialties are published. Much of the material is particularly relevant to the development of novel treatments for disease.