腹腔给予沙利度胺可减少兔大肠切除术后粘连的数量。

Julian W Mall, Wolfgang Schwenk, Andreas W Philipp, Joachim M Müller, Christian Pollmann
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引用次数: 5

摘要

目的:探讨腹腔注射沙利度胺对家兔结肠切除术后粘连形成的影响。设计:对照、随机前瞻性研究。地点:德国大学医院。动物:40只雌性新西兰白兔。干预措施:端到端结肠吻合后,动物被给予沙利度胺200 mg/kg的1%羧甲基纤维素腹腔内或单独给予羧甲基纤维素(每组n = 20)。观察指标:术后第3天(n = 20)和第7天(n = 20)按Tyrell评分粘连评分、体重、行为、白细胞计数(WCC)。结果:两组在行为和体重方面均无差异。沙利度胺组术后第3天、第7天WCCs及粘连评分均低于对照组(p < 0.01)。结论:腹腔注射沙利度胺组术后粘连发生率明显降低。我们的结果表明,沙利度胺可能有助于预防术后粘连。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Thalidomide given intraperitoneally reduces the number of postoperative adhesions after large bowel resection in rabbits.

Objective: To investigate the effect of thalidomide given intraperitoneally on the formation of adhesions after colonic resection in rabbits.

Design: Controlled, randomised prospective study.

Setting: University hospital, Germany.

Animals: 40 female New Zealand White rabbits.

Interventions: After an end-to-end colonic anastomosis the animals were given thalidomide 200 mg/kg in 1% carboxymethylcellulose intraperitoneally or carboxymethylcellulose alone (n = 20 in each group).

Outcome measures: The adhesion score according to Tyrell on day 3 (n = 20) and day 7 (n = 20) postoperatively, weight, behaviour, and white cell count (WCC).

Results: There was no difference in behaviour or weight. On the third postoperative day WCCs and on the seventh postoperative day WCCs and adhesion scores, were lower in the thalidomide group (p < 0.01).

Conclusion: The number of postoperative adhesions was reduced in the group given thalidomide intraperitoneally. Our results suggest that thalidomide may be helpful in the prevention of postoperative adhesions.

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