内啡肽和-内啡肽样肽免疫肽对人白血病细胞体外生长的影响。

Russian journal of immunology : RJI : official journal of Russian Society of Immunology Pub Date : 2002-10-01

Natalya V Malkova, Svetlana B Krasnova, Elena V Navolotskaya, Tatyana A Zargarova, Vladimir S Prasolov

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摘要

研究了-内啡肽和免疫啡肽对人白血病细胞体外生长的影响。结果表明，两种多肽均以剂量依赖的方式促进t淋巴母细胞样细胞的生长。阿片受体拮抗剂纳洛酮不能逆转这些肽对3h -胸腺嘧啶并入t淋巴母细胞样细胞系Jurkat的影响。有趣的是，这些肽对b淋巴母细胞样细胞和早幼粒细胞细胞的生长没有影响，但它们能促进3h -胸腺嘧啶并入髓系细胞。

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Effect of beta-endorphin and beta-endorphin-like peptide immunorphin on the growth of human leukemic cells in vitro.

The influence of beta-endorphin and immunorphin on human leukemic cell growth in vitro was studied. It was shown that both peptides increase the growth of T-lymphoblastoid cells in a dose-dependent manner. The effect of these peptides on the 3H-thymidine incorporation into T-lymphoblastoid cell line Jurkat was not reversed by the antagonist of opioid receptor naloxone. Interestingly, these peptides had no effect on B-lymphoblastoid and promyelocyte cell growth, however they enhance 3H-thymidine incorporation into myeloid cell lines.

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Russian journal of immunology : RJI : official journal of Russian Society of Immunology

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