侵袭性自然杀伤细胞淋巴瘤/白血病。

Po-Shing Lee, Wei-Shou Hwang
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引用次数: 0

摘要

我们报告一例侵袭性NK细胞淋巴瘤/白血病,患者为70岁女性,表现为发热、肝脾肿大、腹膜后淋巴结病和血清CA19-9升高。患者在确诊后4天死亡。在血液和腹膜后淋巴结活检中发现肿瘤NK细胞。他们的表型被广泛的流式细胞术和免疫组织化学研究证实。eb病毒(EBV)相关RNA (EBER)原位杂交阳性。对NK细胞肿瘤的各种形态进行了综述和讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Aggressive natural killer cell lymphoma/leukemia.

We report a case of aggressive natural killer (NK) cell lymphoma/leukemia in a 70-year-old woman presenting with fever, hepatosplenomegaly, retroperitoneal lymphadenopathy, and elevated serum CA19-9. The patient died 4 days after diagnosis. Neoplastic NK cells were identified in the blood and retroperitoneal lymph node biopsy. Their phenotypes were confirmed by extensive flow cytometric and immunohistochemical studies. In situ hybridization for Epstein-Barr virus (EBV)-associated RNA (EBER) was positive. Various forms of NK cell neoplasm were reviewed and discussed.

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