辛伐他汀与持续动态腹膜透析患者内皮功能标志物的关系。

J Malyszko, J S Malyszko, T Hryszko, S Brzosko, M Mysliwiec
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引用次数: 0

摘要

接受持续动态腹膜透析(CAPD)的患者易发生血脂异常,心血管死亡风险高。本研究的目的是评估12例高胆固醇血症CAPD患者6个月的辛伐他汀治疗(睡前10mg)对内皮细胞损伤标志物的影响。治疗1个月后,胆固醇和低密度脂蛋白胆固醇明显下降。辛伐他汀治疗后3个月和6个月血管细胞黏附分子和细胞内黏附分子浓度分别显著降低。治疗6个月后血栓调节蛋白显著下降,而血管性血变因子、p -选择素和e -选择素在辛伐他汀治疗期间保持不变。辛伐他汀是一种有效的降血脂药物,有利于影响内皮功能,可能潜在地减缓动脉粥样硬化的进展,并对接受CAPD的高胆固醇血症患者提供血栓性并发症的保护。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Simvastatin and markers of endothelial function in patients undergoing continuous ambulatory peritoneal dialysis.

Patients undergoing continuous ambulatory peritoneal dialysis (CAPD) are prone to dyslipidemia and have a high risk of cardiovascular death. The aim of this study was to assess the effects of a 6-month treatment with simvastatin (10 mg at bedtime) on markers of endothelial cell injury in 12 hypercholesterolemic CAPD patients. Cholesterol and low-density lipoprotein cholesterol fell significantly after 1 month of therapy. Simvastatin treatment significantly decreased concentrations of vascular cell adhesion molecule and intracellular adhesion molecule after 3 and 6 months of the therapy, respectively. Thrombomodulin decreased significantly after 6 months of the treatment, whereas von Willebrand's factor, P-selectin and E-selectin remained unaltered during simvastatin therapy. Simvastatin, an effective hypolipemic agent, favorably affects endothelial function and may potentially slow the progression of atherosclerosis and confer protection from thrombotic complications in patients with hypercholesterolemia undergoing CAPD.

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