[低氟化物浓度牙膏配方的剂量-反应效应——体外研究]。

Q2 Dentistry
Helena Maria Decico Negri, Jaime Aparecido Cury
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引用次数: 32

摘要

建议6岁以下儿童使用低氟浓度的牙膏,以减少氟斑牙的风险。然而,为了具有抗肿瘤潜能,牙釉质上必须形成松散结合的氟(CaF2)。考虑到CaF2的形成是一个与pH负相关的函数,为了评估剂量效应,我们开发了pH为5.5、275、550和1100 ppm F (NaF/silica)的牙膏。将这些牙膏、安慰剂产品和佳洁士牙膏(阳性对照标准)进行比较。此外,根据总氟(TF)、CaF2和氟磷灰石(FA)在人牙釉质上的形成,评估了牙膏的生物利用度。采用离子特异电极测定氟的用量。结果显示,含550ppm氟的牙膏比安慰剂和含275ppm氟的牙膏更有效,但与阳性对照组相比无显著差异(p > 0.05)。形成的CaF2呈剂量效应相关。综上所述,含550ppm氟的改良配方可被认为与含1100ppm氟的标准牙膏一样有效,而且对于氟斑牙而言,其使用更为安全。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Dose-response effect of a dentifrice formulation with low fluoride concentration - an in vitro study].

The utilization of dentifrices with low fluorine concentration, for children under 6 years of age, has been suggested to reduce the risks of dental fluorosis. However, in order to have anticariogenic potential, the dentifrice should form loosely-bound fluorine (CaF2) on dental enamel. Considering that the formation of CaF2 is a function inversely related to pH, dentifrices with pH 5.5, with 275, 550 and 1,100 ppm F (NaF/silica) were developed in order to assess dose-response effects. A comparison between those dentifrices, a placebo product and the Crest toothpaste (positive control - standard) was carried out. Furthermore, the bioavailability of dentifrices, in terms of formation of total fluorine (TF), CaF2, and fluorapatite (FA) on human dental enamel, was evaluated. An ion-specific electrode was utilized for the determination of the dosage of fluorine. The results revealed that the dentifrice with 550 ppm F was more effective than both the placebo and the dentifrice with 275 ppm, presenting no difference in relation to the positive control (p > 0.05). A dose-effect correlation was observed as to the CaF2 formed. In conclusion, the modified formulation with 550 ppm F can be considered as effective as the standard dentifrice with 1,100 ppm, and its utilization would be safer with regard to dental fluorosis.

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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
0
期刊介绍: Pesquisa Odontológica Brasileira is a new quarterly published journal (January-March, April-June, July-September, October-December), with an annual supplement (Anais da Reunião de Pesquisa Odontológica da SBPqO), by the Sociedade Brasileira de Pesquisa Odontológica [Brazilian Society of Odontological Research] and University of São Paulo. It replaces Revista de Odontologia da Universidade de São Paulo (ISSN 0103-0663).
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