核因子κ B在人腺癌癌细胞中的表达

Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao Pub Date : 2002-01-01

Yao Chen, Ruixiang Li

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引用次数: 0

摘要

目的:核因子κ B在顺式活化中起重要作用，调控多种基因的表达。本研究探讨了肿瘤细胞转移的机制。方法:采用免疫组化方法研究核因子κ B在人转移性直肠腺癌癌细胞中的表达。结果:核因子kappa Bp65在肿瘤周围组织和转移淋巴结的癌细胞中表达。反应产物位于细胞质和细胞核中。结论:核因子κ B在肿瘤细胞中的表达与肿瘤的转移密切相关。

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[The expression of nuclear factor kappa B in cancer cells of human adenocarcinoma].

Objective: Nuclear factor kappa B is very important in cis-activation which regulates the expression of many genes. This study inquired into the mechanism of cancer cell metastasis.

Methods: Immunohistochemical method was used for studying the expression of nuclear factor kappa B in cancer cells of human metastasized rectum adenocarcinoma.

Results: Expressed nuclear factor kappa Bp65 was found in the cancer cells of peritumoral tissues and metastasized lymph nodes. The reaction product was located in the cytoplasm and cytonucleus.

Conclusion: The findings of this study suggest a strong correlation between the expression of nuclear factor kappa B in cancer cells and the metastasis of cancer.

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Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao

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