[γ - l -谷氨酰组胺的肝脏保护作用]。

Voprosy meditsinskoi khimii Pub Date : 2002-09-01

G A Zheltukhina, V E Nebol'sin, V V Krzhechkovskaia, R P Evstigneeva

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引用次数: 0

摘要

采用四氯化碳亚急性肝损伤模型，研究γ - gluha和戊二酰组胺对大鼠脂质过氧化、胆固醇、磷脂和肝脏转氨酶活性的影响。γ - gluha和戊二酰组胺预处理大鼠可防止肝坏死，使血浆丙氨酸转氨酶(ALT)和天冬氨酸转氨酶(AST)活性、肝脏和血浆脂质过氧化、肝脏和血浆脂质谱和胆固醇含量正常化。

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[Hepatoprotective effects of gamma-L-glutamylhistamine].

The influence of gamma-GluHA and glutarylhistamine on the lipid peroxidation, cholesterol, phospholipid and liver aminotransferase activity was investigated using carbon tetrachloride-induced model of subacute liver damage. Pretreatment of rats with gamma-GluHA and glutarylhistamine prevented liver necrosis and normalized activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in blood plasma, lipid peroxidation in the liver and plasma, lipid profiles and cholesterol content in the liver and plasma.

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Voprosy meditsinskoi khimii

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