水作为极性改性剂在2-氧-3-哌啶乙酰胺类似物正相手性分离中的应用。

Enantiomer Pub Date : 2000-01-01

J G Ning

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引用次数: 0

摘要

在使用Chiralcel OD柱的正相手性高效液相色谱中，发现少量的水对于分离药物手性中间体3-哌啶乙酰胺类似物至关重要。对正常流动相的水量进行了优化，提出了一种可能的分离机理。

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Water as polar modifier in normal phase chiral separation of 2-oxo-3-piperidineacetamide analogue.

A small amount of water present in a normal phase chiral HPLC with a Chiralcel OD column was found to be critical and necessary to separate a pharmaceutical chiral intermediate, 3-piperidineacetamide analogue. The amount of water in the normal mobile phase was optimized, and a likely mechanism of the separation was proposed.

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Enantiomer

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