乳腺癌的大剂量化疗——历史失控的危险。

Medscape women's health Pub Date : 2000-05-01
K D Miller, G W Sledge
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引用次数: 0

摘要

乳腺癌仍然是一种常见的毁灭性疾病,在美国,每年约有18万名妇女受其影响,导致4.3万多人死亡。虽然只有10%的患者在诊断时有明显的转移性疾病,但多达三分之一的淋巴结阴性疾病患者和一半淋巴结阳性疾病患者最终发展为转移性乳腺癌。除了少数例外,转移性乳腺癌在很大程度上是无法治愈的,平均生存时间为18至24个月。在过去的30年里,提高生存率的实验室和临床努力都集中在化疗方案的剂量强度上。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High-dose chemotherapy in breast cancer -- the perils of history uncontrolled.

Breast cancer remains a common and devastating disease that affects approximately 180,000 women and results in more than 43,000 deaths annually in the United States. Although only 10% of patients have overt metastatic disease at the time of diagnosis, as many as one third of those who present with lymph node-negative disease and half of those who present with lymph node-positive disease eventually develop metastatic breast cancer. With few exceptions, metastatic breast cancer is largely incurable, and the median duration of survival remains 18 to 24 months. Over the past 3 decades, both laboratory and clinical efforts to increase survival have focused on dose intensity in chemotherapy regimens.

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