F H Schilling, F Berthold, R Erttmann, J Michaelis, C Spix, J Sander, K Schwarz, J Treuner
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Population-based and controlled study to evaluate neuroblastoma screening at one year of age in Germany: interim results.
Background: The German Neuroblastoma Screening Project is the first controlled and population-based screening study to evaluate the presumed benefit of neuroblastoma mass screening at 1 year of age (10-18 months).
Procedure: Screening takes place in 6 of the 16 German states; children from the remainder serve as controls. The German Childhood Cancer Registry enables a mostly complete follow-up and detection of false-negative patients.
Results: Up to December, 1999, 1,199,165 children were examined for urinary catecholamine metabolites and 124 cases of neuroblastoma were detected preclinically, giving a detection rate of 10.3/100,000. Within this cohort, 33 false-negative cases were found.
Conclusions: The results of this screening program will be crucial for further implementation of neuroblastoma screening.
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