去松果体雄性大鼠褪黑素与抗利尿激素的合成。

M Juszczak, E Bojanowska, R Dabrowski
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引用次数: 9

摘要

已知松果体激素,褪黑激素,在不同的实验条件下,可以改变大鼠神经垂体激素的分泌。本研究的目的是利用秋水仙碱法研究褪黑素对松果体切除或假手术大鼠下丘脑抗利尿激素生物合成率的影响。为了评估秋水仙碱是否影响这些动物的神经垂体功能,还测量了神经垂体和血浆加压素水平。与假手术动物相比,松果体切除后抗利尿激素合成率增加,褪黑激素强烈抑制松果体切除后激素合成的增加。松果体去除后血浆抗利尿激素浓度显著升高,褪黑激素减弱了这种作用。相反,松果体切除术后神经垂体后叶加压素含量明显降低,但褪黑素没有进一步改变。因此,褪黑激素抑制松果体切除大鼠抗利尿激素的合成和分泌。目前的结果证实了我们之前关于松果体对抗利尿激素合成和释放的抑制作用的报道,并提示褪黑激素可能介导松果体对抗利尿激素能神经元活动的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Melatonin and the synthesis of vasopressin in pinealectomized male rats.

The pineal hormone, melatonin, is known to modify, under different experimental conditions, neurohypophysial hormone secretion in the rat. The aim of this study was to investigate the effect of melatonin on the vasopressin biosynthesis rate in the hypothalamus of either pinealectomized or sham-operated rats, using the colchicine method. To estimate whether colchicine affects the function of the neurohypophysis in these animals, the neurohypophysial and plasma vasopressin levels were also measured. The vasopressin synthesis rate was increased after pineal removal, when compared with sham-operated animals, and melatonin strongly inhibited the rise in the hormone synthesis due to pinealectomy. After pineal removal plasma vasopressin concentration was significantly elevated, and melatonin attenuated this effect. On the contrary, the neurohypophysial vasopressin content was significantly decreased after pinealectomy, but it was not further modified by melatonin.Thus, melatonin suppresses the synthesis and secretion of vasopressin in pinealectomized rats. The present results confirm our previous reports as to the inhibitory impact of the pineal on both vasopressin synthesis and release and suggest that melatonin may mediate the effect of the pineal gland on vasopressinergic neuron activity.

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