反社会,物质依赖和DRD5基因:初步研究。

M M Vanyukov, H B Moss, B B Kaplan, G P Kirillova, R E Tarter
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引用次数: 38

摘要

一项针对成年欧美人DRD5位点微卫星多态性的试点人群研究显示,其与男性和女性的对立违抗性障碍(ODD)和女性的成年反社会人格障碍(ASPD)的儿童症状计数有关。与儿童品行障碍症状计数无关联。ODD在女性中介导基因型与反社会人格障碍的关系。ODD和ASPD均未显著介导基因型与物质依赖倾向(SD)之间的关系。这些数据表明,DRD5基因座参与了SD倾向和反社会性的变异和性别二态性,以及反社会性的发育连续性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antisociality, substance dependence, and the DRD5 gene: a preliminary study.

A pilot population-based study of a microsatellite polymorphism at the DRD5 locus in adult European-Americans showed its association with childhood symptom counts for oppositional defiant disorder (ODD) in males and females and adult antisocial personality disorder (ASPD) in females. No association with childhood conduct disorder symptom count was observed. ODD mediated the genotype-ASPD relationship in females. Neither ODD nor ASPD significantly mediated the relationship between the genotype and the liability to substance dependence (SD). The data suggest involvement of the DRD5 locus in the variation and sexual dimorphism of SD liability and antisociality and in the developmental continuity of antisociality.

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