强力霉素预防猪实验性胸膜肺炎放线杆菌感染的效果。

I Luque, C Tarradas, L Carrasco, E Torroella, C Artigas, A Perea
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引用次数: 2

摘要

采用胸膜肺炎放线杆菌血清1型气溶胶攻毒模型,研究了在饲料中添加强力霉素控制猪胸膜肺炎的有效性。两组10只动物被用于挑战,一组是“药物组”,另一组是“未药物组”。第三组4只动物作为“对照组”。给药组连续8天饲喂含有250 p.p.m.强力霉素(HIPRAMIX/DOXI)的饲料,第5天攻毒。“对照组”的猪未观察到任何临床症状。“未用药组”的4只动物在注射后48小时内死亡,并出现急性胸膜肺炎的临床和病变证据。存活最初48小时的动物的临床症状逐渐减轻,并显示出与亚急性-慢性形式的疾病相似的病变。然而,“药物组”中只有一只动物表现出慢性胸膜肺炎的临床症状。在喂食不含多西环素的饲料(70%)的动物的肺组织中,胸膜肺炎单胞杆菌的再分离更为明显,与急性和亚急性病变的存在相一致。然而,这种微生物只能从属于“用药组”的一只动物身上重新分离出来。由此得出结论,用250 ppm的强西环素(HIPRAMIX/DOXI)治疗猪可预防胸膜肺炎假单胞菌引起的疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effectiveness of doxycycline in the prevention of an experimental infection with Actinobacillus pleuropneumoniae in pigs.

The effectiveness of medication with doxycycline in feed in the control of pleuropneumonia in pigs was tested using an Actinobacillus pleuropneumoniae serotype 1 aerosol challenge model. Two groups of 10 animals were used for the challenge, a 'medicated group' and an 'unmedicated group'. A third group of four animals was used as a 'control group'. Pigs from the medicated group were provided with feed containing 250 p.p.m. doxycycline (HIPRAMIX/DOXI) for 8 consecutive days and were challenged on the fifth day of treatment. No clinical signs were observed in pigs from the 'control group'. Four animals from the 'unmedicated group' died within the first 48 h after challenge with clinical and lesional evidence of an acute form of pleuropneumonia. Clinical signs of animals surviving the first 48 h were progressively less severe and showed lesions similar to those described for subacute-chronic forms of the disease. However, only one animal from the 'medicated group' showed clinical signs of a chronic form of pleuropneumonia. Reisolation of A. pleuropneumoniae was more evident from lung tissues of animals fed the doxycycline-free feed (70%), coinciding with the presence of both acute and subacute lesions. However, the micro-organism could be reisolated from only one animal which belonged to the 'medicated group'. It is concluded that the treatment of pigs with 250 p.p.m. doxycycline (HIPRAMIX/DOXI) prevents disease caused by A. pleuropneumoniae.

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