豚鼠血管紧张素1型受体的分子克隆。

Biological signals and receptors Pub Date : 2000-09-01 DOI:10.1159/000014644

Y Hosoda, I Fujino, K Akagawa, A Kuwahara

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引用次数: 0

摘要

从豚鼠肝脏中克隆了血管紧张素1型受体(AT(1)R) cDNA的一级结构。豚鼠AT(1)R (GP-AT(1)R) cDNA克隆含有一个1077 bp的开放阅读框，编码一个由359个氨基酸残基组成的蛋白。GP-AT(1)R氨基酸序列在哺乳动物中具有92%的同源性。GP-AT(1)R在肝脏、肾脏、肾上腺、心脏和结肠中表达。

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Molecular cloning of guinea pig angiotensin type 1 receptor.

The primary structure of cDNA encoding of the angiotensin type 1 receptor (AT(1)R) was cloned from guinea pig liver. Guinea pig AT(1)R (GP-AT(1)R) cDNA clone contains a 1,077-bp open reading frame which encodes a protein consisting of 359 amino acid residues. GP-AT(1)R amino acid sequence showed a 92% level of identity among mammalian species. GP-AT(1)R is expressed in liver, kidney, adrenal gland, heart and colon.

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Biological signals and receptors

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