H. Bönisch, F. Runkel, C Roubert, B. Giros, M. Brüss
{"title":"人类去西帕胺敏感的去甲肾上腺素转运体及其功能中特定氨基酸的重要性","authors":"H. Bönisch, F. Runkel, C Roubert, B. Giros, M. Brüss","doi":"10.1111/j.1365-2680.1999.tb00005.x","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p><b>1</b> This article gives a short overview of the physiology, pharmacology and the molecular biology of the human Na<sup>+</sup>/CI<sup>-</sup> -dependent noradrenaline transporter (hNAT) and its gene.</p>\n <p><b>2</b> Furthermore, naturally occurring variants of the hNAT are described and new results obtained through site-directed mutagenesis of the hNAT are presented, which increase our understanding about structural domains and amino acids critically involved in substrate, cosubstrate and inhibitor binding to the hNAT.</p>\n </div>","PeriodicalId":100151,"journal":{"name":"Autonomic and Autacoid Pharmacology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2009-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2680.1999.tb00005.x","citationCount":"18","resultStr":"{\"title\":\"The human desipramine-sensitive noradrenaline transporter and the importance of defined amino acids for its function\",\"authors\":\"H. Bönisch, F. Runkel, C Roubert, B. Giros, M. Brüss\",\"doi\":\"10.1111/j.1365-2680.1999.tb00005.x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p><b>1</b> This article gives a short overview of the physiology, pharmacology and the molecular biology of the human Na<sup>+</sup>/CI<sup>-</sup> -dependent noradrenaline transporter (hNAT) and its gene.</p>\\n <p><b>2</b> Furthermore, naturally occurring variants of the hNAT are described and new results obtained through site-directed mutagenesis of the hNAT are presented, which increase our understanding about structural domains and amino acids critically involved in substrate, cosubstrate and inhibitor binding to the hNAT.</p>\\n </div>\",\"PeriodicalId\":100151,\"journal\":{\"name\":\"Autonomic and Autacoid Pharmacology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-01-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1111/j.1365-2680.1999.tb00005.x\",\"citationCount\":\"18\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Autonomic and Autacoid Pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2680.1999.tb00005.x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Autonomic and Autacoid Pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2680.1999.tb00005.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The human desipramine-sensitive noradrenaline transporter and the importance of defined amino acids for its function
1 This article gives a short overview of the physiology, pharmacology and the molecular biology of the human Na+/CI- -dependent noradrenaline transporter (hNAT) and its gene.
2 Furthermore, naturally occurring variants of the hNAT are described and new results obtained through site-directed mutagenesis of the hNAT are presented, which increase our understanding about structural domains and amino acids critically involved in substrate, cosubstrate and inhibitor binding to the hNAT.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
