H. Bönisch, F. Runkel, C Roubert, B. Giros, M. Brüss
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The human desipramine-sensitive noradrenaline transporter and the importance of defined amino acids for its function
1 This article gives a short overview of the physiology, pharmacology and the molecular biology of the human Na+/CI- -dependent noradrenaline transporter (hNAT) and its gene.
2 Furthermore, naturally occurring variants of the hNAT are described and new results obtained through site-directed mutagenesis of the hNAT are presented, which increase our understanding about structural domains and amino acids critically involved in substrate, cosubstrate and inhibitor binding to the hNAT.
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