硝普塞通过减少收缩延迟和时间来减弱心肌昏迷。

R J Leone, P M Scholz, H R Weiss
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引用次数: 0

摘要

我们假设硝普赛引起的环GMP增加可以逆转心肌昏迷,这可以通过舒张期局部功的减少来实现。对8只开胸麻醉犬进行心脏仪器测量左心室压力,并利用微型力传感器和超声尺寸晶体记录局部心肌力学。基线(CON)后,左冠状动脉前降支(LAD)闭塞15分钟,随后30分钟恢复(STUN)。然后开始冠状动脉内滴注硝普钠(NP) (4 μ g/kg/ min)。区域缩短的延迟时间(msec)从昏迷后的18+/-13显著增加到73+/-13,但NP将其减少到49+/-18。总区域工作(g*mm/min)在基线(1368+/-401 CON)与昏迷(1320+/-333 STUN)不变,但NP后减少(961+/-240)。达到力量发展峰值的时间(msec)在眩晕时从284+/-13 (CON)显著增加到333+/-11 (STUN),但在NP后减少到269+/-12。收缩期的作功百分比从96%+/-2% (CON)降低到77%+/-7% (STUN),但在NP组中又恢复到98%+/-1%。两种处理均未影响区域氧气消耗。环GMP在麻醉下没有变化(2.9+/-0.3-2.9+/-0.4 pmol/g),但在NP作用下显著增加(4.6+/-0.6)。这些数据表明硝普钠可以减轻局部心肌昏迷,增加循环GMP,减少收缩延迟,增加收缩时做功的比例,缩短缩短时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nitroprusside attenuates myocardial stunning through reduced contractile delay and time.

We hypothesized that myocardial stunning would be reversed through increased cyclic GMP caused by nitroprusside, and that this would be accomplished through a decreased proportion of regional work during diastole. Hearts were instrumented to measure left ventricular pressure, and regional myocardial mechanics were recorded using a miniature force transducer and ultrasonic dimension crystals in eight open-chest anesthetized dogs. Following baseline (CON), the left anterior descending coronary artery (LAD) was occluded for 15 min, followed by a 30-min recovery (STUN). Then intracoronary LAD infusion of sodium nitroprusside (NP) (4 microg/kg/ min) was begun. The time delay (msec) to regional shortening increased significantly from 18+/-13 to 73+/-13 following stunning, but was reduced to 49+/-18 by NP. Total regional work (g*mm/min) at baseline (1368+/-401 CON) was unchanged with stunning (1320+/-333 STUN), but reduced (961+/-240) following NP. Time to peak force development (msec) increased significantly with stunning from 284+/-13 (CON) to 333+/-11 (STUN), but was reduced to 269+/-12 following NP. The percentage work during systole was reduced from 96%+/-2% (CON) to 77%+/-7% (STUN), but returned to 98%+/-1% with NP. Regional O2 consumption was unaffected by either treatment. Cyclic GMP was unchanged by stunning (2.9+/-0.3-2.9+/-0.4 pmol/g) but increased significantly with NP (4.6+/-0.6). These data indicated that regional myocardial stunning could be attenuated by nitroprusside, which increased cyclic GMP, decreased contractile delay, increased the proportion of work done during systole, and reduced time of shortening.

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