海龟Dmrt1在性分化前的温度依赖性表达。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2000-03-01

J R Kettlewell, C S Raymond, D Zarkower

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引用次数: 0

摘要

脊椎动物采用不同的策略，包括染色体和非染色体，来确定发育中的胚胎的性别。在爬行动物中，依赖温度的性别决定(TSD)是很常见的。在性别分化前的关键时期的孵化温度决定了胚胎未来的性别，可能是通过改变温度依赖性调节因子的活性或表达来实现的。在这里，我们研究了Dmrt1基因在海龟中的表达，Dmrt1基因是哺乳动物和鸟类性发育的候选调节因子。在性别决定期间，生殖嵴/中肾复合体中Dmrt1 mRNA在促雄温度下比在促雌温度下更丰富。Dmrt1是第一个在性分化之前表现出温度依赖性表达的基因，可能在爬行动物的性发育中起关键作用。创世纪26:174- 178,2000。

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Temperature-dependent expression of turtle Dmrt1 prior to sexual differentiation.

Vertebrates employ varied strategies, both chromosomal and nonchromosomal, to determine the sex of the developing embryo. Among reptiles, temperature-dependent sex determination (TSD) is common. The temperature of incubation during a critical period preceding sexual differentiation determines the future sex of the embryo, presumably by altering the activity or expression of a temperature-dependent regulatory factor(s). Here we examine the expression of the Dmrt1 gene, a candidate regulator of mammalian and avian sexual development, in the turtle. During the sex-determining period, Dmrt1 mRNA is more abundant in genital ridge/mesonephros complexes at male-promoting than at female-promoting temperatures. Dmrt1 is the first gene found to show temperature-dependent expression prior to sexual differentiation, and may play a key role in sexual development in reptiles. genesis 26:174-178, 2000.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.