肌注奥美拉唑对马24小时内胃酸分泌的影响。

A Sandin, F M Andrews, J A Nadeau, T J Doherty, G Nilsson
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引用次数: 15

摘要

肌肉注射奥美拉唑(0.25或1.0 mg/kg体重)的效果;研究了5匹长期植入胃插管的马在24 h内胃液体积、总酸输出量(TAO)和pH值的变化。对照组无论是基础分泌还是刺激分泌(8微克/kg体重/小时),体积(NS)和TAO (P < 0.01, NS)逐渐降低,pH逐渐升高(P < 0.05, NS)。奥美拉唑显著降低平均基础TAO (LD) 49 +/- 6% (HD)和88 +/- 3% (HD),刺激TAO分别降低64 +/- 2%和97 +/- 1%。对照组的基础pH为2.1 ~ 4.2,奥美拉唑治疗后的基础pH为2.8 ~ 4.1 (LD)和2.4 ~ 6.6 (HD)。刺激后对应的pH值分别为2.6 ~ 3.3、3.9 ~ 4.9和5.4 ~ 7.2。奥美拉唑的生物利用度为70 ~ 80%。由于给药技术的简单性和较高的生物利用度,肌内给药可能是治疗马胃溃疡的一种实用且便宜的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of intramuscular omeprazole on gastric acid secretion in horses over a twenty-four hour period.

The effect of intramuscular (i.m.) omeprazole (0.25 or 1.0 mg/kg bwt; LD and HD), respectively, on volume, total acid output (TAO) and pH of the gastric juice was studied during 24 h in 5 horses with a chronically implanted gastric cannula. Whether secretion in controls was basal or stimulated with pentagastrin (8 micrograms/kg bwt/h), volume (NS) and TAO (P < 0.01, NS) gradually decreased and pH increased (P < 0.05, NS). Omeprazole significantly reduced the average basal TAO by 49 +/- 6% (LD) and 88 +/- 3% (HD) and the stimulated TAO by 64 +/- 2% and 97 +/- 1%. Basal pH in controls was 2.1-4.2 and after omeprazole treatment, pH 2.8-4.1 (LD) and 2.4-6.6 (HD). After stimulation, the corresponding pH values were 2.6-3.3, 3.9-4.9 and 5.4-7.2. The biological availability of omeprazole was 70-80%. Due to the simplicity of the administration technique and the higher biological availability, intramuscular administration may offer a practical and less expensive way of treating gastric ulcers in horses.

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