{"title":"参与学习和记忆的中枢烟碱受体亚型。","authors":"L J Chen, R Z Chen","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>To observe the effects of different subtypes of central nicotinic receptor on learning and memory.</p><p><strong>Methods: </strong>Passive avoidance response, including step-down avoidance and step-through avoidance in mice and long-term potentiation (LTP) in rat hippocampal slices.</p><p><strong>Results: </strong>Hexamethonium (C6) 7 micrograms/mouse and kappa-bungarotoxin (kappa-BTX) 0.6 microgram/mouse inhibited the acquisition of avoidance conditioning in mice, and kappa-BTX yielded this effect with a dose-response relationship. kappa-BTX 1 mumol.L-1 suppressed the induction of LTP (P < 0.05), but not normal synaptic transmission and maintenance of LTP in rat hippocampal slices.</p><p><strong>Conclusion: </strong>The subtypes of central nicotinic receptor sensitive to kappa-BTX play an important role in learning and memory.</p>","PeriodicalId":24002,"journal":{"name":"Zhongguo yao li xue bao = Acta pharmacologica Sinica","volume":"20 8","pages":"725-8"},"PeriodicalIF":0.0000,"publicationDate":"1999-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Subtypes of central nicotinic receptors involved in learning and memory.\",\"authors\":\"L J Chen, R Z Chen\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>To observe the effects of different subtypes of central nicotinic receptor on learning and memory.</p><p><strong>Methods: </strong>Passive avoidance response, including step-down avoidance and step-through avoidance in mice and long-term potentiation (LTP) in rat hippocampal slices.</p><p><strong>Results: </strong>Hexamethonium (C6) 7 micrograms/mouse and kappa-bungarotoxin (kappa-BTX) 0.6 microgram/mouse inhibited the acquisition of avoidance conditioning in mice, and kappa-BTX yielded this effect with a dose-response relationship. kappa-BTX 1 mumol.L-1 suppressed the induction of LTP (P < 0.05), but not normal synaptic transmission and maintenance of LTP in rat hippocampal slices.</p><p><strong>Conclusion: </strong>The subtypes of central nicotinic receptor sensitive to kappa-BTX play an important role in learning and memory.</p>\",\"PeriodicalId\":24002,\"journal\":{\"name\":\"Zhongguo yao li xue bao = Acta pharmacologica Sinica\",\"volume\":\"20 8\",\"pages\":\"725-8\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1999-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zhongguo yao li xue bao = Acta pharmacologica Sinica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhongguo yao li xue bao = Acta pharmacologica Sinica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Subtypes of central nicotinic receptors involved in learning and memory.
Aim: To observe the effects of different subtypes of central nicotinic receptor on learning and memory.
Methods: Passive avoidance response, including step-down avoidance and step-through avoidance in mice and long-term potentiation (LTP) in rat hippocampal slices.
Results: Hexamethonium (C6) 7 micrograms/mouse and kappa-bungarotoxin (kappa-BTX) 0.6 microgram/mouse inhibited the acquisition of avoidance conditioning in mice, and kappa-BTX yielded this effect with a dose-response relationship. kappa-BTX 1 mumol.L-1 suppressed the induction of LTP (P < 0.05), but not normal synaptic transmission and maintenance of LTP in rat hippocampal slices.
Conclusion: The subtypes of central nicotinic receptor sensitive to kappa-BTX play an important role in learning and memory.
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