人胎儿肠内分泌细胞分化的组织学和免疫细胞化学资料。

I S Lolova, M S Davidoff, D E Itzev
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引用次数: 0

摘要

研究了人胎儿中嗜铁蛋白、嗜金蛋白、5-羟色胺(5-HT)-、生长抑素(SOM)-、胆囊收缩素(CCK)-、P物质(SP)-、蛋氨酸-脑啡肽(Met-Enk)-和血管活性肠多肽(VIP)-免疫反应性肠内分泌细胞(EECs)的分化情况。在妊娠第7周至第12周期间,十二指肠和直肠的EECs频率显著增加。EECs的分化在小肠的远端和大肠的近端进行。在24-25周的胎儿中,回肠和结肠中EECs的频率也增加了。观察到EECs类型的出现和分化有不同的时间过程。在任何年龄均未检测到Met-Enk和vip免疫反应性内分泌细胞。在年龄最大的胎儿中,内分泌细胞类型的频率和形态存在区域差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Histological and immunocytochemical data on the differentiation of intestinal endocrine cells in human fetus.

The differentiation of the argyrophil, argentaffin, 5-hydroxytryptamine (5-HT)-, somatostatin (SOM)-, cholecystokinin (CCK)-, substance P (SP)-, methionine-enkephalin (Met-Enk)- and vasoactive intestinal polypeptide (VIP)-immunoreactive entero-endocrine cells (EECs) was examined in human fetuses. A great increase in the frequency of EECs in the duodenum and the rectum was observed between the 7th and 12th gestation week. The differentiation of the EECs advanced distally in the small intestine and proximally in the large intestine. In 24-25-week-old fetuses the frequency of the EECs was also increased in the ileum and the colon. A different time-course of the appearance and differentiation of the types of EECs was observed. Met-Enk- and VIP-immunoreactive endocrine cells were not detected at any age. A regional difference in the frequency and morphology of the endocrine cell types was observed in the eldest fetuses.

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