三苯二氟硅酸四丁基铵(TBAT)在6-氟嘌呤核苷合成中的应用。

Nucleosides & nucleotides Pub Date : 1999-10-01 DOI:10.1080/07328319908044885

V Gurvich, H Y Kim, R P Hodge, C M Harris, T M Harris

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引用次数: 7

摘要

已发现四丁基三苯二氟硅酸铵(TBAT)是6-氯嘌呤核苷转化为6-氟嘌呤衍生物的有用试剂。6-氯嘌呤核苷与三甲胺反应生成季三甲铵盐，在DMF中用TBAT原位处理生成6-氟衍生物，产率为59-72%。

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Utilization of tetrabutylammonium triphenyldifluorosilicate (TBAT) in the synthesis of 6-fluoropurine nucleosides.

Tetrabutylammonium triphenydifluorosilicate (TBAT) has been found to be a useful reagent for the conversion of 6-chloropurine nucleosides to 6-fluoropurine derivatives. The 6-chloropurine nucleosides were reacted with trimethylamine to form quaternary trimethylammonium salts which were treated in situ with TBAT in DMF to effect conversion to the 6-fluoro derivatives in yields of 59-72%.

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Nucleosides & nucleotides

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