化学修饰的寡核苷酸与RNA发夹的双链茎的结合。

Nucleosides & nucleotides Pub Date : 1999-06-01 DOI:10.1080/07328319908044810

K Aupeix, J J Toulmé

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引用次数: 2

摘要

我们监测了三聚体形成的低聚嘧啶与HIV-1中负责gag-pol移码的RNA发夹的双链茎的结合。而用5，丙基-C取代C的效果有限，使用肽核酸12mer导致低聚物/RNA复合物的稳定性急剧降低。

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Binding of chemically-modified oligonucleotides to the double-stranded stem of an RNA hairpin.

We monitored the binding of triplex-forming oligopyrimidines to the double-stranded stem of the RNA hairpin responsible for the gag-pol frameshift in HIV-1. Whereas the substitution of 5, propynyl-C for C had a limited effect, the use of a Peptide Nucleic Acid 12mer led to a drastic reduction in the stability of the oligomer/RNA complex.

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Nucleosides & nucleotides

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