7-硝基吲唑对l-clausenamide和高频刺激诱导大鼠海马长时程增强的影响。

Zhongguo yao li xue bao = Acta pharmacologica Sinica Pub Date : 1999-04-01

M R Zhao, J T Zhang

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引用次数: 0

摘要

目的:研究选择性神经元一氧化氮合酶(nNOS)抑制剂7-硝基茚唑对l-克劳胺(Cla)诱导的大鼠海马长期增强(LTP)的体内拮抗作用。方法:采用细胞外记录技术测定麻醉大鼠海马齿状回(DG)的诱发电位群体峰(PS)。结果:7-硝基茚唑2 nmol icv和l -精氨酸225 mg对高频(100 Hz)刺激或cl5 nmol icv诱导的LTP有阻断作用(P < 0.01)。kg-1 i.p.对7-硝基茚唑的抑制作用显著(P < 0.01)。结论:nNOS产生的一氧化氮在cla诱导的海马LTP中起作用。

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Effects of 7-nitroindazole on long-term potentiation induced by l-clausenamide and high-frequency stimulation in rat hippocampus in vivo.

Aim: To study the antagonistic effect of selective neuronal nitric-oxide synthase (nNOS) inhibitor 7-nitroindazole on the long-term potentiation (LTP) induced by l-clausenamide (Cla) in rat hippocampus in vivo.

Methods: Population spike (PS) of evoked potentials was determined by extracellular recording technique in the hippocampal dentate gyrus (DG) of anesthetized rats.

Results: 7-Nitroindazole 2 nmol icv blocked the induction of LTP elicited by high-frequency (100 Hz) stimulation or Cla 5 nmol icv (P < 0.01), and L-arginine 225 mg.kg-1 i.p. prevented the action of 7-nitroindazole (P < 0.01).

Conclusion: Nitric oxide produced by nNOS plays a role in the induction of Cla-induced LTP in hippocampus.

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Zhongguo yao li xue bao = Acta pharmacologica Sinica

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