人脑肿瘤组织蛋白酶L。净化和内容物]。

Ukrainskii biokhimicheskii zhurnal (1978) Pub Date : 1998-09-01

V I Chernaia

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引用次数: 0

摘要

半胱氨酸组织蛋白酶L从人脑中分离纯化1242倍。测定组织蛋白酶L ph -最适值、Vmax、K(m)、溶酶体起源和硫醇性质。研究了组织蛋白酶L活性在不同组织结构、组织发生及恶性程度的脑肿瘤中的分布。与正常脑组织相比，大多数肿瘤组织蛋白酶L的活性更高。

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[Cathepsin L from human brain tumor. Purification and contents].

Cysteine cathepsin L was isolated and purified 1242-fold from human brain. Cathepsin L pH-optimum, Vmax, K(m), lysosomal origin and thiol nature were determined. The distribution of cathepsin L activity in human brain tumours of different histological structure, histogenesis and degree of malignization was studied. The activity of cathepsin L in most the tumours was found to be higher compared to the normal brain tissue.

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Ukrainskii biokhimicheskii zhurnal (1978)

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