N Silva, L O'Bryan, E Medeiros, H Holand, J Suleiman, J S de Mendonca, N Patronas, S G Reed, H G Klein, H Masur, R Badaro
{"title":"hiv感染者的克氏锥虫脑膜脑炎。","authors":"N Silva, L O'Bryan, E Medeiros, H Holand, J Suleiman, J S de Mendonca, N Patronas, S G Reed, H G Klein, H Masur, R Badaro","doi":"10.1097/00042560-199904010-00004","DOIUrl":null,"url":null,"abstract":"<p><p>Five cases of Trypanosoma cruzi meningoencephalitis in HIV-infected patients are reported. All patients presented with mass lesions on head computed tomographic scan, trypanosomes in the cerebrospinal fluid and failure to respond to antitoxoplasmosis therapy. Benznidazole therapy was associated with clinical improvement in 1 patient. Another 4 patients had T cruzi identified in a peripheral smear. T cruzi needs to be considered in the differential diagnosis of HIV-infected patients with central nervous system mass lesions if they have a history of appropriate exposure.</p>","PeriodicalId":14731,"journal":{"name":"Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association","volume":"20 4","pages":"342-9"},"PeriodicalIF":0.0000,"publicationDate":"1999-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"54","resultStr":"{\"title\":\"Trypanosoma cruzi meningoencephalitis in HIV-infected patients.\",\"authors\":\"N Silva, L O'Bryan, E Medeiros, H Holand, J Suleiman, J S de Mendonca, N Patronas, S G Reed, H G Klein, H Masur, R Badaro\",\"doi\":\"10.1097/00042560-199904010-00004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Five cases of Trypanosoma cruzi meningoencephalitis in HIV-infected patients are reported. All patients presented with mass lesions on head computed tomographic scan, trypanosomes in the cerebrospinal fluid and failure to respond to antitoxoplasmosis therapy. Benznidazole therapy was associated with clinical improvement in 1 patient. Another 4 patients had T cruzi identified in a peripheral smear. T cruzi needs to be considered in the differential diagnosis of HIV-infected patients with central nervous system mass lesions if they have a history of appropriate exposure.</p>\",\"PeriodicalId\":14731,\"journal\":{\"name\":\"Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association\",\"volume\":\"20 4\",\"pages\":\"342-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1999-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"54\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/00042560-199904010-00004\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/00042560-199904010-00004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Trypanosoma cruzi meningoencephalitis in HIV-infected patients.
Five cases of Trypanosoma cruzi meningoencephalitis in HIV-infected patients are reported. All patients presented with mass lesions on head computed tomographic scan, trypanosomes in the cerebrospinal fluid and failure to respond to antitoxoplasmosis therapy. Benznidazole therapy was associated with clinical improvement in 1 patient. Another 4 patients had T cruzi identified in a peripheral smear. T cruzi needs to be considered in the differential diagnosis of HIV-infected patients with central nervous system mass lesions if they have a history of appropriate exposure.