哺乳动物卵子激活的早期事件。

IF 6 1区医学 Q1 OBSTETRICS & GYNECOLOGY

Human reproduction Pub Date : 1998-12-01 DOI:10.1093/humrep/13.suppl_4.133

T Raz, R Shalgi

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引用次数: 28

摘要

受精的精子在哺乳动物的卵子中启动一系列事件，称为“卵子激活”。这些生化和形态学事件包括细胞内Ca2+浓度([Ca2+]i)的短暂升高，这一方面导致皮质反应(CR)和多精子的建立，另一方面导致减数分裂和后来的胚胎有丝分裂的恢复。[Ca2+]i的初始增加似乎对卵子激活的起始至关重要。然而，另一种第二信使蛋白激酶C (PKC)也被认为是卵子激活某些方面的可能诱导剂。本文综述了哺乳动物精卵相互作用的早期事件，并讨论了Ca2+和PKC在卵子激活中的可能作用。

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Early events in mammalian egg activation.

The fertilizing spermatozoon initiates a series of events in the mammalian egg, referred to as 'egg activation'. These biochemical and morphological events include a transient rise in intracellular Ca2+ concentration ([Ca2+]i) that leads to the cortical reaction (CR) and the establishment of the block to polyspermy on the one hand, and to the resumption of meiosis and later embryonic mitotic divisions on the other. The initial increase in [Ca2+]i appears to be critical for the initiation of egg activation. However, another second messenger, protein kinase C (PKC), was also suggested as a possible inducer of some aspects of egg activation. The review focuses on early events during mammalian sperm-egg interaction and discusses possible roles of Ca2+ and PKC in egg activation.

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来源期刊

Human reproduction 医学-妇产科学

CiteScore

10.90

自引率

6.60%

发文量

1369

审稿时长

1 months

期刊介绍： Human Reproduction features full-length, peer-reviewed papers reporting original research, concise clinical case reports, as well as opinions and debates on topical issues. Papers published cover the clinical science and medical aspects of reproductive physiology, pathology and endocrinology; including andrology, gonad function, gametogenesis, fertilization, embryo development, implantation, early pregnancy, genetics, genetic diagnosis, oncology, infectious disease, surgery, contraception, infertility treatment, psychology, ethics and social issues.