慢性酒精摄入对溃疡愈合过程中颊黏膜bFGF和Cdk2表达的影响。

B L Slomiany, J Piotrowski, A Slomiany
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引用次数: 8

摘要

在这项研究中,我们研究了慢性酒精摄入对口腔溃疡愈合过程中受体结合的碱性成纤维细胞生长因子(bFGF-R)和细胞周期蛋白依赖性激酶(Cdk2)表达之间相互作用的影响。以含酒精或对照液体喂养5周的大鼠,口腔黏膜外用醋酸诱导慢性溃疡。两组溃疡愈合均伴有颊黏膜bFGF和Cdk2表达升高。对照组溃疡在10天内愈合,在愈合第2天出现bFGF(2.6倍)和Cdk2(2.4倍)的最大诱导。相比之下,酒精饮食组溃疡愈合明显延迟(14天),与bFGF和Cdk2表达最大值转移到第4-6天有关,其值降低了35%至38%。研究结果表明,慢性酒精摄入对由bfgf受体激活启动并由Cdk2传播的信号事件产生不利影响,这些信号事件推动了对快速粘膜修复至关重要的细胞周期进程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of chronic alcohol ingestion on buccal mucosal expression of bFGF and Cdk2 during ulcer healing.

In this study, we investigated the effect of chronic alcohol ingestion on the interplay between the receptor-bound basic fibroblast growth factor (bFGF-R) and the expression of cyclin-dependent kinase (Cdk2) in buccal mucosa during ulcer healing. Chronic ulceration was induced by a topical application of acetic acid to the buccal mucosa of rats maintained for 5 weeks on alcohol-containing or control liquid diet. In both groups, the ulcer healing was accompanied by an increase in buccal mucosal expression of bFGF and Cdk2. In the control group, the ulcer healed within 10 days and maximum induction in bFGF (2.6-fold) and Cdk2 (2.4-fold) occurred by the 2nd day of healing. In contrast, the alcohol diet group showed a marked delay in ulcer healing (14 days), associated with the shift in maximum of bFGF and Cdk2 expression to the 4-6th day, and the values were reduced by 35 to 38%. The findings show that chronic alcohol ingestion exerts detrimental effect on the signaling events initiated by bFGF-receptor activation and propagated by Cdk2 that propels the cell cycle progression essential for rapid mucosal repair.

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