HLA-DPB1表型研究显示，喀麦隆农村人群中存在DPB1*6301。

European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics Pub Date : 1998-10-01

K V Poulton, L J Kennedy, J Ross, W Thomson, J C Mbanya, W E Ollier

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引用次数: 0

摘要

最近报道的几个HLA-DPB1等位基因仅在单个家族或个体中被发现，并且在全球范围内的分布未知。许多新的DPB1等位基因似乎是由于类似基因转换的事件而出现的，这可能使DPB1等位基因变异定位于它们最初被发现的人群。使用两种基于ssop的分型方法，我们在喀麦隆农村的一名个体中鉴定出HLA-DPB1*6301，以前仅在墨西哥裔美国人家庭中报道过。通过外显子2的序列分型证实了DPB1*6301的存在。

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A study of HLA-DPB1 phenotypes reveals DPB1*6301 in a rural population from Cameroon.

Several recently reported HLA-DPB1 alleles have only been identified in a single family or individuals and are of unknown distribution world-wide. Many new DPB1 alleles appear to arise as a result of gene conversion-like events, which may localize variant DPB1 alleles to the population in which they were first identified. Using two SSOP-based typing methods in parallel, we have identified HLA-DPB1*6301 in an individual from rural Cameroon which has previously only been reported in a family of Mexican-American origin. The presence of DPB1*6301 was confirmed by sequence-based typing of exon 2.

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European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics

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