[硫胺对六氯苯作用的影响]。

G L Vilas, D Ureta, M C Sanchez García, C Aldonatti, L C San Martín de Viale, M C Ríos de Molina
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引用次数: 0

摘要

慢性给药六氯苯,与或不同时给药噻丁胺进行了分析。六氯苯单独产生特征性卟啉症,通过尿液排泄增加和肝脏卟啉积累,以及尿卟啉原脱羧酶活性降低来检测。肝偶联二烯含量变化不大,丙二醛含量升高,但未达到统计学意义水平。这些结果表明发生了轻微的脂质过氧化过程。硫辛酰胺(25 mg/kg体重)的毒性作用大于保护性作用,在其第一步脱羧时,谷氨酸转氨酶活性升高,肝脏尿卟啉原脱羧酶活性降低。这些结果可能表明:1)高剂量硫胺降低了尿卟啉原脱羧酶的活性,掩盖了其通过自由基产生对六氯苯的保护作用;2)尿卟啉原脱羧酶是测定体内六氯苯自由基产生的一个比共轭二烯或丙二醛水平更敏感的参数。在任何情况下,硫胺在低剂量和无毒剂量下进行试验,也许可以通过其自由基清除能力来防止六氯苯的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Effect of the thioctamide in relation to the hexachlorobenzene action].

Chronic administration of Hexachlorobenzene, with or without the simultaneous administration of Tioctamide was assayed. Hexachlorobenzene alone produced the characteristic porphyria, detected through an increase of the urinary excretion and the hepatic accumulation of porphyrins, as well as by a decrease of the Uroporphyrinogen decarboxylase activity. The content of hepatic conjugated dienes did not change while those of malondialdehyde increased, although without reaching levels of statistical significance. These results would indicate the occurrence of an light lipid peroxidation process. The Thioctamide (25 mg/kg body weight) produced more noxious effects than protective ones, which were detected by a high level of Glutamate piruvate transaminase activity and a decrease of the hepatic Uroporphyrinogen decarboxylase activity, at its first step of decarboxylation. These results might indicate that: 1) high doses of Thioctamide decreases Uroporphyrinogen decarboxylase activity, masking its possible protective effect from Hexachlorobenzene's action through free radicals production and, 2) Uroporphyrinogen decarboxylase is a more sensitive parameter than conjugated dienes or malondialdehyde levels to assay the free radicals in vivo Hexachlorobenzene production. In any case, the Thioctamide assayed in lower and non toxic doses, perhaps might protect against Hexachlorobenzene's action through its free radical scavenger ability.

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