脂肪酸去饱和酶的结构和表达

Dmitry A. Los , Norio Murata
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引用次数: 504

摘要

脂肪酸去饱和酶是在脂肪酸酰基链中引入双键的酶。它们存在于所有生物群体中,即细菌、真菌、植物和动物,并在维持生物膜的正常结构和功能方面发挥关键作用。去饱和酶的特点是存在三个保守的组氨酸轨道,它们被认为是构成酶的铁结合活性中心。本文综述了近年来在蓝藻、植物和动物中不同类型脂肪酸去饱和酶的结构和表达的研究进展。讨论了各个去饱和酶在温度驯化中的作用和去饱和酶基因的调控原理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Structure and expression of fatty acid desaturases

Fatty acid desaturases are enzymes that introduce double bonds into fatty acyl chains. They are present in all groups of organisms, i.e., bacteria, fungi, plants and animals, and play a key role in the maintenance of the proper structure and functioning of biological membranes. The desaturases are characterized by the presence of three conserved histidine tracks which are presumed to compose the Fe-binding active centers of the enzymes. Recent findings on the structure and expression of different types of fatty acid desaturase in cyanobacteria, plants and animals are reviewed in this article. Roles of individual desaturases in temperature acclimation and principles of regulation of the desaturase genes are discussed.

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