{"title":"端粒酶在脑肿瘤中的预后意义","authors":"Grosso, Schiffer","doi":"10.1007/s003290050083","DOIUrl":null,"url":null,"abstract":"<p><p>Telomeres help to maintain chromosomal stability and integrity. They are progressively lost, conditioning aging and mortality. Telomerase enzyme activation stabilizes the telomere length, permitting the proliferation of cancer cells. Four papers are reviewed dealing with increased expression of telomerase associated with increased labelling index of MIB-1 (Ki-67) and malignancy in astrocytomas, ependymomas, and oligodendrogliomas. Telomerase expression can be utilized for differentiating malignant from benign tumors with histological resemblance. The significance of telomerase in tumor progression is discussed within the field of brain neoplasias.</p>","PeriodicalId":79482,"journal":{"name":"Critical reviews in neurosurgery : CR","volume":"8 4","pages":"244-7"},"PeriodicalIF":0.0000,"publicationDate":"1998-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s003290050083","citationCount":"2","resultStr":"{\"title\":\"Prognostic significance of telomerase in brain tumors\",\"authors\":\"Grosso, Schiffer\",\"doi\":\"10.1007/s003290050083\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Telomeres help to maintain chromosomal stability and integrity. They are progressively lost, conditioning aging and mortality. Telomerase enzyme activation stabilizes the telomere length, permitting the proliferation of cancer cells. Four papers are reviewed dealing with increased expression of telomerase associated with increased labelling index of MIB-1 (Ki-67) and malignancy in astrocytomas, ependymomas, and oligodendrogliomas. Telomerase expression can be utilized for differentiating malignant from benign tumors with histological resemblance. The significance of telomerase in tumor progression is discussed within the field of brain neoplasias.</p>\",\"PeriodicalId\":79482,\"journal\":{\"name\":\"Critical reviews in neurosurgery : CR\",\"volume\":\"8 4\",\"pages\":\"244-7\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1998-07-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/s003290050083\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Critical reviews in neurosurgery : CR\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s003290050083\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical reviews in neurosurgery : CR","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s003290050083","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Prognostic significance of telomerase in brain tumors
Telomeres help to maintain chromosomal stability and integrity. They are progressively lost, conditioning aging and mortality. Telomerase enzyme activation stabilizes the telomere length, permitting the proliferation of cancer cells. Four papers are reviewed dealing with increased expression of telomerase associated with increased labelling index of MIB-1 (Ki-67) and malignancy in astrocytomas, ependymomas, and oligodendrogliomas. Telomerase expression can be utilized for differentiating malignant from benign tumors with histological resemblance. The significance of telomerase in tumor progression is discussed within the field of brain neoplasias.
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