I Bello, A Perez, A M Torres, M V Hernández, P López Saura
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引用次数: 9
摘要
激素和细胞因子的可溶性受体已被描述。它们可以作为各自配体的天然阻断剂。天然可溶性干扰素γ受体（sIFN gamma R）只在尿液中被分离出来并确定了其特征。通过对类风湿性关节炎（RA）患者和对照组的人（hu）血浆进行固定化 hu IFN gamma 或 IFN gamma R alpha 链抗体的层析，我们分离出了 sIFN gamma R。我们在类风湿性关节炎患者的血浆中检测到的 sIFN gamma R 含量明显高于健康人。
High levels of soluble IFN gamma receptor alpha chain in the plasma of rheumatoid arthritis patients.
Soluble receptors for hormones and cytokines have been described. They can serve as natural blockers of their respective ligands. The natural soluble interferon gamma receptor (sIFN gamma R) has been isolated and characterized only in urine. Chromatography of human (hu) plasma from rheumatoid arthritis (RA) patients and controls on immobilized hu IFN gamma or antibodies against IFN gamma R alpha chain permitted us to isolate the sIFN gamma R. The receptor isolated from one control is a protein with a molecular weight between 60-67 kDa depending on the presence of reducing agents. We detected a significantly higher level of plasma sIFN gamma R in patients with rheumatoid arthritis than in apparently healthy subjects.
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