滑膜液脂蛋白在类风湿性关节炎慢性滑膜炎中的作用

Pamela E Prete M.D. , Arzu Gurakar-Osborne Ph.D.
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引用次数: 29

摘要

活动期类风湿关节炎患者的滑液中的脂质比正常的滑液和其他炎性关节病患者的滑液中的脂质升高。关于这些脂质的作用,人们提出了各种各样的假设。本研究提供的证据表明,这些脂质可能通过参与关节间隙内的花生四烯通路而导致类风湿关节炎的滑膜炎。磷脂酶A2活性、磷脂、前列腺素E2和白三烯B4在未经治疗的类风湿患者的滑液和血浆中存在相关性,并与骨关节炎患者进行了比较。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Contribution of Synovial Fluid Lipoproteins to the Chronic Synovitis of Rheumatoid Arthritis

Lipids in the synovial fluid of patients with active rheumatoid arthritis are elevated compared to normal synovial fluid and that of other inflammatory arthropathies. Various assumptions about the role of these lipids have been made. This study offers evidence that these lipids may contribute to the synovitis in rheumatoid arthritis through participation in the arachidonic pathway within the joint space. Phospholipase A2 activity, phospholipids, prostaglandin E2, and leukotriene B4 have been correlated in the synovial fluid and plasma of untreated rheumatoid patients and compared with that of patients with osteoarthritis.

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