压力调节离体兔心外膜动脉的反应性

J.L. García-Roldán, M.J. Alonso, J. Marín
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引用次数: 1

摘要

1 .在内皮完整的兔心外膜冠状动脉(367±44 μm .d)受压时,观察前列腺素F2α (PGF2α)和腺苷(ADO)对其自发张力的反应程度。2动脉插管,用自动视频灌注系统记录动脉直径的变化。在60 mmHg稳定期,将血管分为两组,一组纵向拉伸为未拉伸初始长度的+20% (Lo),另一组纵向拉伸为+35% (Lo),形成自发张力。在这两种情况下,通过将血管内压力以30 mmHg (dp/dt = 15 mmHg s−1)的渐变步骤从30改变到120 mmHg,获得了直径-压力曲线。3 . 1 μm PGF2α对+35% Lo的动脉缩径大于+20% Lo的动脉缩径。同样,1 μm ADO +35% Lo的动脉的增加大于+20% Lo。4血管内血流(40 μl min - 1)增加了动脉的张力水平。PGF2α的加入增强了这种色调,与+35% Lo拉伸和无流动的效果相似,而ADO的效果则有所增强。这些数据表明PGF2α和ADO的血管舒缩反应受心外膜动脉纵向拉伸程度的调节。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pressure modulates the reactivity of isolated rabbit epicardial arteries

1 The magnitude of responses to prostaglandin F (PGF) and adenosine (ADO) in pressurized rabbit epicardial coronary arteries (367 ± 44 μm o.d.) with intact endothelium was assessed when they developed spontaneous tone.

2 The arteries were cannulated and changes in arterial diameter registered with an automated video perfusion system. The vessels, in the stabilization period at 60 mmHg, were divided into two groups, one exposed to a longitudinal stretch of +20% of unstretched initial length (Lo), and the other to +35% Lo, which developed spontaneous tone. In both cases, diameter–pressure curves were obtained by changing the intravascular pressure from 30 to 120 mmHg in aleatory steps of 30 mmHg (dp/dt = 15 mmHg s−1).

3 Diameter reduction of the arteries with stretch of +35% Lo in response to 1 μm PGF was greater than that with stretch of +20% Lo. Likewise, increase of the arteries that had +35% Lo in response to 1 μm ADO was greater than with +20% Lo.

4 Intravascular flow (40 μl min−1) increased the tone level of arteries. The addition of PGF enhanced this tone which was similar to that obtained with a stretch of +35% Lo and no flow, whereas the effect of ADO was increased.

5 These data indicate that the vasomotor responses of PGF and ADO are modulated by the degree of longitudinal stretch in epicardial arteries.

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