外膜、内皮和动脉粥样硬化。

B van der Loo, J F Martin
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引用次数: 29

摘要

尽管有许多理论,动脉粥样硬化发展的初始环境仍然不清楚。动脉粥样硬化动物模型的建立是基于动脉粥样硬化起源的不同理论,这些理论认为动脉粥样硬化起源于血管内膜表面。最近的一种动脉粥样硬化模型涉及通过在动脉周围放置一个中空的硅胶环来对血管进行血管周围操作。在这个模型中,早期人类动脉粥样硬化的几个特征在7天内产生。假设血管血管闭塞后的动脉壁缺氧可能是动脉粥样硬化的初始病变,因此在某些情况下动脉粥样硬化是动脉壁外层的疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The adventitia, endothelium and atherosclerosis.

Despite many theories, the initiating circumstances for the development of atherosclerosis remain obscure. The development of animal models of atherosclerosis was based upon the different theories of the origins of atherosclerosis which suggested that it originates at the intimal surface of the vessel. A more recent model of atherosclerosis involves perivascular manipulation of the vessel by positioning of a hollow silastic collar around the artery. In this model, several of the features seen in early human atherosclerosis are generated within a period of 7 days. It is hypothesized that arterial wall hypoxia following occlusion of the vasa vasorum may be the initial lesion of atherosclerosis, and hence that in some cases atherosclerosis is a disease of the outer layers of the arterial wall.

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