{"title":"血栓素双阻滞剂(KDI-792)对2型糖尿病患者下肢不同部位血流的急性影响——多普勒超声和激光多普勒血流仪的研究","authors":"Hirohito Sone, Yukichi Okuda, Yoko Tsurushima, Michiko Asano, Seiji Suzuki, Yasushi Kawakami, Kamejiro Yamashita","doi":"10.1016/S0090-6980(97)00057-9","DOIUrl":null,"url":null,"abstract":"<div><p>The acute effects of a newly synthesized thromboxane dual blocker (KDI-792), a combined thromboxane synthase inhibitor and receptor antagonist, on lower limb circulation were examined using two-dimensional color and pulse Doppler ultrasonography and laser Doppler flowmetry. A randomized single-masked, placebo-controlled trial was performed on 36 type 2 diabetic patients with minimally impaired baseline flow. The anatomical cross-sectional area (CSA), maximum flow velocity (MFV) and flow volume index (FVI) in the right dorsal pedis artery (DPA) and right femoral artery (FA) were determined by Doppler ultrasonography before and 45 and 90 minutes after the administration of either 100 or 200 mg of KDI-792 to the dose groups or placebo to the control group. Periflux blood flow (PBF) in the right foot was determined simultaneously by laser Doppler flowmetry. Both CSA and MFV in the dose groups were significantly increased in both the FA and DPA. FVI was markedly increased from 21.4 ± 3.7 to 68.3 ± 26.8 in the DPA (M ± SD, P < 0.01) and from 365.4 ± 35.3 to 771.7 ± 75.7 in the FA (P < 0.01) in the 200 mg dose group. In the 100 mg dose group, FVI was markedly increased from 20.0 ± 8.7 to 68.3 ± 26.8 (P < 0.01) in the DPA and from 372.5 ± 130.0 to 677.5 ± 187.8 (P < 0.01) in the FA. PBF was also increased in both dose groups (from 4.15 ± 1.4 to 7.0 ± 4.0 ml/min/100 g tissue in the 200 mg dose group, P < 0.01), whereas there were no significant changes in either measurement in the control group. There were no significant changes in pulse rate or blood pressure after administration in either the dosage group or the placebo group. These and previous findings indicate that a single administration of KDI-792 markedly increases lower limb blood flow and might have a more potent vasodilating effect than that of prostaglandin I<sub>2</sub> derivatives.</p></div>","PeriodicalId":20653,"journal":{"name":"Prostaglandins","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1997-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0090-6980(97)00057-9","citationCount":"2","resultStr":"{\"title\":\"Acute Effects of Thromboxane Dual Blocker (KDI-792) on Different Portions of Lower Limb Blood Flow—A Study Using Doppler Ultrasonography and Laser Doppler Flowmetry in Type 2 Diabetic Patients\",\"authors\":\"Hirohito Sone, Yukichi Okuda, Yoko Tsurushima, Michiko Asano, Seiji Suzuki, Yasushi Kawakami, Kamejiro Yamashita\",\"doi\":\"10.1016/S0090-6980(97)00057-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The acute effects of a newly synthesized thromboxane dual blocker (KDI-792), a combined thromboxane synthase inhibitor and receptor antagonist, on lower limb circulation were examined using two-dimensional color and pulse Doppler ultrasonography and laser Doppler flowmetry. A randomized single-masked, placebo-controlled trial was performed on 36 type 2 diabetic patients with minimally impaired baseline flow. The anatomical cross-sectional area (CSA), maximum flow velocity (MFV) and flow volume index (FVI) in the right dorsal pedis artery (DPA) and right femoral artery (FA) were determined by Doppler ultrasonography before and 45 and 90 minutes after the administration of either 100 or 200 mg of KDI-792 to the dose groups or placebo to the control group. Periflux blood flow (PBF) in the right foot was determined simultaneously by laser Doppler flowmetry. Both CSA and MFV in the dose groups were significantly increased in both the FA and DPA. FVI was markedly increased from 21.4 ± 3.7 to 68.3 ± 26.8 in the DPA (M ± SD, P < 0.01) and from 365.4 ± 35.3 to 771.7 ± 75.7 in the FA (P < 0.01) in the 200 mg dose group. In the 100 mg dose group, FVI was markedly increased from 20.0 ± 8.7 to 68.3 ± 26.8 (P < 0.01) in the DPA and from 372.5 ± 130.0 to 677.5 ± 187.8 (P < 0.01) in the FA. PBF was also increased in both dose groups (from 4.15 ± 1.4 to 7.0 ± 4.0 ml/min/100 g tissue in the 200 mg dose group, P < 0.01), whereas there were no significant changes in either measurement in the control group. There were no significant changes in pulse rate or blood pressure after administration in either the dosage group or the placebo group. These and previous findings indicate that a single administration of KDI-792 markedly increases lower limb blood flow and might have a more potent vasodilating effect than that of prostaglandin I<sub>2</sub> derivatives.</p></div>\",\"PeriodicalId\":20653,\"journal\":{\"name\":\"Prostaglandins\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1997-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0090-6980(97)00057-9\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0090698097000579\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0090698097000579","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Acute Effects of Thromboxane Dual Blocker (KDI-792) on Different Portions of Lower Limb Blood Flow—A Study Using Doppler Ultrasonography and Laser Doppler Flowmetry in Type 2 Diabetic Patients
The acute effects of a newly synthesized thromboxane dual blocker (KDI-792), a combined thromboxane synthase inhibitor and receptor antagonist, on lower limb circulation were examined using two-dimensional color and pulse Doppler ultrasonography and laser Doppler flowmetry. A randomized single-masked, placebo-controlled trial was performed on 36 type 2 diabetic patients with minimally impaired baseline flow. The anatomical cross-sectional area (CSA), maximum flow velocity (MFV) and flow volume index (FVI) in the right dorsal pedis artery (DPA) and right femoral artery (FA) were determined by Doppler ultrasonography before and 45 and 90 minutes after the administration of either 100 or 200 mg of KDI-792 to the dose groups or placebo to the control group. Periflux blood flow (PBF) in the right foot was determined simultaneously by laser Doppler flowmetry. Both CSA and MFV in the dose groups were significantly increased in both the FA and DPA. FVI was markedly increased from 21.4 ± 3.7 to 68.3 ± 26.8 in the DPA (M ± SD, P < 0.01) and from 365.4 ± 35.3 to 771.7 ± 75.7 in the FA (P < 0.01) in the 200 mg dose group. In the 100 mg dose group, FVI was markedly increased from 20.0 ± 8.7 to 68.3 ± 26.8 (P < 0.01) in the DPA and from 372.5 ± 130.0 to 677.5 ± 187.8 (P < 0.01) in the FA. PBF was also increased in both dose groups (from 4.15 ± 1.4 to 7.0 ± 4.0 ml/min/100 g tissue in the 200 mg dose group, P < 0.01), whereas there were no significant changes in either measurement in the control group. There were no significant changes in pulse rate or blood pressure after administration in either the dosage group or the placebo group. These and previous findings indicate that a single administration of KDI-792 markedly increases lower limb blood flow and might have a more potent vasodilating effect than that of prostaglandin I2 derivatives.