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{"title":"人血液单核细胞和肺泡巨噬细胞对白细胞介素-4抑制前列腺素内过氧化物合酶-2的敏感性差异","authors":"Ryszard Dworski, James R Sheller","doi":"10.1016/S0090-6980(97)89598-6","DOIUrl":null,"url":null,"abstract":"<div><p><em><span>Interleukin-4<span><span> (IL-4) is a potent immunomodulatory cytokine synthesized and released by Th2 lymphocytes, mast cells and </span>basophils<span><span>. It has important effects on monocyte/macrophage cell lines, regulating the secretion of several cytokines, and the production of eicosanoids. In human monocytes and macrophages, IL-4 increases the expression of 15-lipoxygenase and 15-HETE production, but suppresses the inducible isoform of the prostaglandin H </span>synthase (PGHS-2) enzyme and prostanoid synthesis. Prostanoids, in particular prostaglandin E</span></span></span><sub>2</sub> (PGE<sub>2</sub><span><span>) have important functions in modulating inflammatory and fibrotic processes. We compared the effect of IL-4 on the expression of PGHS-2 in human alveolar macrophages (AM) and blood monocytes (BM) activated with physiologically distinct stimuli, </span>lipopolysaccharide (LPS) or IL-1</span></em> in vitro. <em>The induction of PGHS-2 mRNA and protein, and prostanoid synthesis by all stimuli was inhibited by exogenous IL-4 in both cell types. However, monocytes were more susceptible to this effect of IL-4 than alveolar macrophages</em>. © <em>1997 by Elsevier Science Inc.</em></p></div>","PeriodicalId":20653,"journal":{"name":"Prostaglandins","volume":"53 4","pages":"Pages 237-251"},"PeriodicalIF":0.0000,"publicationDate":"1997-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0090-6980(97)89598-6","citationCount":"13","resultStr":"{\"title\":\"Differential Sensitivities of Human Blood Monocytes and Alveolar Macrophages to the Inhibition of Prostaglandin Endoperoxide Synthase-2 by Interleukin-4\",\"authors\":\"Ryszard Dworski, James R Sheller\",\"doi\":\"10.1016/S0090-6980(97)89598-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><em><span>Interleukin-4<span><span> (IL-4) is a potent immunomodulatory cytokine synthesized and released by Th2 lymphocytes, mast cells and </span>basophils<span><span>. It has important effects on monocyte/macrophage cell lines, regulating the secretion of several cytokines, and the production of eicosanoids. In human monocytes and macrophages, IL-4 increases the expression of 15-lipoxygenase and 15-HETE production, but suppresses the inducible isoform of the prostaglandin H </span>synthase (PGHS-2) enzyme and prostanoid synthesis. Prostanoids, in particular prostaglandin E</span></span></span><sub>2</sub> (PGE<sub>2</sub><span><span>) have important functions in modulating inflammatory and fibrotic processes. We compared the effect of IL-4 on the expression of PGHS-2 in human alveolar macrophages (AM) and blood monocytes (BM) activated with physiologically distinct stimuli, </span>lipopolysaccharide (LPS) or IL-1</span></em> in vitro. <em>The induction of PGHS-2 mRNA and protein, and prostanoid synthesis by all stimuli was inhibited by exogenous IL-4 in both cell types. However, monocytes were more susceptible to this effect of IL-4 than alveolar macrophages</em>. © <em>1997 by Elsevier Science Inc.</em></p></div>\",\"PeriodicalId\":20653,\"journal\":{\"name\":\"Prostaglandins\",\"volume\":\"53 4\",\"pages\":\"Pages 237-251\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1997-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0090-6980(97)89598-6\",\"citationCount\":\"13\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0090698097895986\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0090698097895986","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 13
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