佛罗里达未宣布的流行病:恶性黑色素瘤。

D Kamath, A B Cantor, F Glass, N Fenske, C W Cruse, K Wells, D Rapaport, R DeConti, J Messina, D Reintgen
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摘要

与世界其他地区早期诊断的趋势相反,在佛罗里达州,黑色素瘤仍在较晚期阶段被发现。其特征是诊断时病变变厚,以出血、瘙痒、溃疡和垂直生长增加为特征。在佛罗里达州H. Lee Moffitt癌症中心对1,626例皮肤黑色素瘤患者进行的一项研究中,肿瘤厚度、克拉克水平和原发肿瘤中溃疡的存在这三个预后因素在1987-1994年的8年期间保持相对稳定。尽管在过去四年中肿瘤厚度没有变化,但死亡率正在下降,可能是由于更有效的治疗。尽管死亡率有了这些明显的改善,但必须在恶性黑色素瘤的早期发现方面取得明确的进展,通过在全州范围内启动非专业公共和专业教育项目。此外,建议在全州范围内建立皮肤表型1和2的高加索人群筛查计划,也将有助于未来黑色素瘤的早期诊断,改善这些患者的前景,并开始解决佛罗里达州的一个主要公共卫生问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Florida's undeclared epidemic: malignant melanoma.

Contrary to the trend of early diagnosis observed in other parts of the world, in Florida melanoma is still being discovered in the more advanced stages. This is characterized by thicker lesions at diagnosis, which are hallmarked by bleeding, itching, ulceration, and increased vertical growth. In a study of 1,626 cutaneous melanoma patients at the H. Lee Moffitt Cancer Center in Florida, three prognostic factors, tumor thickness, Clark level, and presence of ulceration in the primary tumor, have remained relatively constant over an eight-year period (1987-1994). Despite the lack of change in tumor thickness in the last four years, mortality rate is decreasing, possibly due to more effective treatments. Regardless of these apparent improvements in mortality rates, definite progress must be made in the early detection of malignant melanoma through the initiation of statewide programs of lay public and professional education. In addition, it is proposed that the establishment of statewide screening programs of the Caucasian population with skin phenotypes 1 and 2 will also facilitate the early diagnosis of melanoma in the future, improve the outlook for these patients, and begin to address a major public health problem in the state of Florida.

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