杂手性肽的晶体结构。第二部分。tert-Boc-valyl-D-alanyl-leucyl-alanyl甲氧基。

The journal of peptide research : official journal of the American Peptide Society Pub Date : 1997-01-01

V Nagarajan, V Pattabhi, A Johnson, V Bobde, S Durani

{"title":"杂手性肽的晶体结构。第二部分。tert-Boc-valyl-D-alanyl-leucyl-alanyl甲氧基。","authors":"V Nagarajan, V Pattabhi, A Johnson, V Bobde, S Durani","doi":"","DOIUrl":null,"url":null,"abstract":"Crystal structure of a heterochiral peptide, viz. Boc-Val1-D-Ala2-Leu3-Ala4-OMe with a D chiral residue in the second position of a sequence, has been determined [a = 40.44(1), b = 4.887(5), c = 15.381(5) A, beta = 109.6(1)degrees, space group C2, Z = 4, R = 0.11]. The peptide is in a parallel beta-sheet structure terminated by a distinct local bend. The structure is established by N-H...O as well as C alpha-H...O hydrogen bonds. The contiguous C alpha-H...O hydrogen bond observed in this structure is an unique observation.","PeriodicalId":22827,"journal":{"name":"The journal of peptide research : official journal of the American Peptide Society","volume":"49 1","pages":"74-9"},"PeriodicalIF":0.0000,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Crystal structures of heterochiral peptides. Part II. tert-Boc-valyl-D-alanyl-leucyl-alanyl methoxide.\",\"authors\":\"V Nagarajan, V Pattabhi, A Johnson, V Bobde, S Durani\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Crystal structure of a heterochiral peptide, viz. Boc-Val1-D-Ala2-Leu3-Ala4-OMe with a D chiral residue in the second position of a sequence, has been determined [a = 40.44(1), b = 4.887(5), c = 15.381(5) A, beta = 109.6(1)degrees, space group C2, Z = 4, R = 0.11]. The peptide is in a parallel beta-sheet structure terminated by a distinct local bend. The structure is established by N-H...O as well as C alpha-H...O hydrogen bonds. The contiguous C alpha-H...O hydrogen bond observed in this structure is an unique observation.\",\"PeriodicalId\":22827,\"journal\":{\"name\":\"The journal of peptide research : official journal of the American Peptide Society\",\"volume\":\"49 1\",\"pages\":\"74-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1997-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The journal of peptide research : official journal of the American Peptide Society\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The journal of peptide research : official journal of the American Peptide Society","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

确定了具有D手性残基的杂手性肽boc - val1 -D- ala2 - leu3 - ala1 - ome的晶体结构[a = 40.44(1)， b = 4.887(5)， c = 15.381(5) a， β = 109.6(1)度，空间群C2, Z = 4, R = 0.11]。肽呈平行的β片结构，末端有明显的局部弯曲。结构是由N-H…O和C - h…O氢键。连续的C α - h…在这个结构中观察到的O氢键是一个独特的观察。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

Crystal structures of heterochiral peptides. Part II. tert-Boc-valyl-D-alanyl-leucyl-alanyl methoxide.

Crystal structure of a heterochiral peptide, viz. Boc-Val1-D-Ala2-Leu3-Ala4-OMe with a D chiral residue in the second position of a sequence, has been determined [a = 40.44(1), b = 4.887(5), c = 15.381(5) A, beta = 109.6(1)degrees, space group C2, Z = 4, R = 0.11]. The peptide is in a parallel beta-sheet structure terminated by a distinct local bend. The structure is established by N-H...O as well as C alpha-H...O hydrogen bonds. The contiguous C alpha-H...O hydrogen bond observed in this structure is an unique observation.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

The journal of peptide research : official journal of the American Peptide Society

自引率

0.00%

发文量