肿瘤前细胞基因组不稳定性的调控。

Cancer surveys Pub Date : 1996-01-01

T D Tlsty

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引用次数: 0

摘要

最近对TP53作用的深入研究揭示了维持基因组完整性的信号转导途径。TP53是第一个被证明参与这些途径的基因，但其他几个基因的突变也可能有类似的最终效应。这些信号转导途径的表征将为提高肿瘤诊断和治疗效果提供进一步的靶点。

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Regulation of genomic instability in preneoplastic cells.

Recent insights into the action of TP53 have uncovered signal transduction pathways that maintain genomic integrity. TP53 was the first gene demonstrated to be involved in these pathways, but mutation of several other genes can have a similar terminal effect. The characterization of these signal transduction pathways should provide further targets for the improvement of neoplastic diagnosis as well as therapeutic efficacy.

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Cancer surveys

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