应激激活蛋白激酶途径。

Cancer surveys Pub Date : 1996-01-01
J R Woodgett, J Avruch, J Kyriakis
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引用次数: 0

摘要

SAPKs代表了一种新的通道,通过它,细胞损伤或损伤的影响传递到细胞核,从而影响基因表达。SAPK通路由至少四个水平的蛋白激酶组成,这些蛋白激酶被一系列对细胞生长不利的药物激活。与结构相关的MAPK途径不同,应激诱导的激酶不是有丝分裂所必需的,而是诱导生长停滞。考虑到炎症细胞因子、再灌注损伤和化疗药物对该通路的调节,确定该通路的生理功能可能为诊断和治疗干预提供新的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The stress activated protein kinase pathway.

The SAPKs represent novel conduits through which the effects of cellular insults or injury are transmitted to the nucleus to influence gene expression. The SAPK pathway consists of at least four levels of protein kinases that are activated by a wide range of agents that adversely affect cell growth. Unlike the structurally related MAPK pathway, the stress induced kinases are not required for mitogenesis and instead induce growth arrest. Given the modulation of the pathway by inflammatory cytokines, reperfusion injury and chemotherapeutics, determination of the physiological functions of the pathway may uncover new possibilities for diagnosis and therapeutic intervention.

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