小gtpase Rho家族对肌动蛋白、细胞骨架、整合素和细胞生长的调控。

Cancer surveys Pub Date : 1996-01-01

N A Hotchin, A Hall

{"title":"小gtpase Rho家族对肌动蛋白、细胞骨架、整合素和细胞生长的调控。","authors":"N A Hotchin, A Hall","doi":"","DOIUrl":null,"url":null,"abstract":"The Rho family of small GTP binding proteins play a key part in regulating the actin cytoskeleton and cell adhesion through integrin receptors. In addition, these proteins regulate signal transduction pathways essential for normal cell growth. Many of the molecules that regulate Rho have oncogenic activity, suggesting that members of the Rho family may have an important role in tumour formation.","PeriodicalId":77062,"journal":{"name":"Cancer surveys","volume":"27 ","pages":"311-22"},"PeriodicalIF":0.0000,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Regulation of the actin cytoskeleton, integrins and cell growth by the Rho family of small GTPases.\",\"authors\":\"N A Hotchin, A Hall\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The Rho family of small GTP binding proteins play a key part in regulating the actin cytoskeleton and cell adhesion through integrin receptors. In addition, these proteins regulate signal transduction pathways essential for normal cell growth. Many of the molecules that regulate Rho have oncogenic activity, suggesting that members of the Rho family may have an important role in tumour formation.\",\"PeriodicalId\":77062,\"journal\":{\"name\":\"Cancer surveys\",\"volume\":\"27 \",\"pages\":\"311-22\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer surveys\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer surveys","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

小GTP结合蛋白Rho家族通过整合素受体在调节肌动蛋白细胞骨架和细胞粘附中起关键作用。此外，这些蛋白调节正常细胞生长所必需的信号转导通路。许多调节Rho的分子具有致癌活性，这表明Rho家族的成员可能在肿瘤形成中起重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

Regulation of the actin cytoskeleton, integrins and cell growth by the Rho family of small GTPases.

The Rho family of small GTP binding proteins play a key part in regulating the actin cytoskeleton and cell adhesion through integrin receptors. In addition, these proteins regulate signal transduction pathways essential for normal cell growth. Many of the molecules that regulate Rho have oncogenic activity, suggesting that members of the Rho family may have an important role in tumour formation.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Cancer surveys

自引率

0.00%

发文量