A. Jawerbaum, E.T. Gonzalez, A. Faletti, V. Novaro, A. Vitullo, M.A.F. Gimeno
{"title":"非胰岛素依赖型糖尿病大鼠模型中卵母细胞复合物改变前列腺素生成","authors":"A. Jawerbaum, E.T. Gonzalez, A. Faletti, V. Novaro, A. Vitullo, M.A.F. Gimeno","doi":"10.1016/S0090-6980(96)00098-6","DOIUrl":null,"url":null,"abstract":"<div><p>Ovulation, oocyte maturation and PGE and PGF<sub>2α</sub> production by oocyte-cumulus complexes were evaluated in rats with non-insulin-dependent diabetes induced by neonatal streptozotocin. Diabetic rats had normal estrous cycles, but ovulated a lower number of oocytes at estrus. When oocytes from control and diabetic rats obtained at proestrus were matured “in vitro” during 1, 2 or 4 hours (hr) of culture, differences were not found in the percent of germinal vesicle breakdown between both experimental groups. PGE and PGF<sub>2α</sub> accumulation was higher in ovulated oocyte-cumulus complexes when compared to immature or “in vitro”-matured oocyte-cumulus complexes in both normal and diabetic rats. When control and diabetic rats are compared, more PGE and PGF<sub>2α</sub> accumulation was observed in immature, “in vitro”-matured and in ovulated oocytecumulus complexes.</p><p>A lower number of oocytes ovulated and increased oocyte-cumulus complexes prostaglandin production has been observed in this mildly diabetic experimental model. These abnormalities are similar to those previously found when 10 day embryos were evaluated in noninsulin-dependent diabetic rats.</p></div>","PeriodicalId":20653,"journal":{"name":"Prostaglandins","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1996-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0090-6980(96)00098-6","citationCount":"11","resultStr":"{\"title\":\"Altered prostanoid production by cumulus-oocyte complexes in a rat model of non-insulin-dependent diabetes mellitus\",\"authors\":\"A. Jawerbaum, E.T. Gonzalez, A. Faletti, V. Novaro, A. Vitullo, M.A.F. Gimeno\",\"doi\":\"10.1016/S0090-6980(96)00098-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Ovulation, oocyte maturation and PGE and PGF<sub>2α</sub> production by oocyte-cumulus complexes were evaluated in rats with non-insulin-dependent diabetes induced by neonatal streptozotocin. Diabetic rats had normal estrous cycles, but ovulated a lower number of oocytes at estrus. When oocytes from control and diabetic rats obtained at proestrus were matured “in vitro” during 1, 2 or 4 hours (hr) of culture, differences were not found in the percent of germinal vesicle breakdown between both experimental groups. PGE and PGF<sub>2α</sub> accumulation was higher in ovulated oocyte-cumulus complexes when compared to immature or “in vitro”-matured oocyte-cumulus complexes in both normal and diabetic rats. When control and diabetic rats are compared, more PGE and PGF<sub>2α</sub> accumulation was observed in immature, “in vitro”-matured and in ovulated oocytecumulus complexes.</p><p>A lower number of oocytes ovulated and increased oocyte-cumulus complexes prostaglandin production has been observed in this mildly diabetic experimental model. These abnormalities are similar to those previously found when 10 day embryos were evaluated in noninsulin-dependent diabetic rats.</p></div>\",\"PeriodicalId\":20653,\"journal\":{\"name\":\"Prostaglandins\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1996-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0090-6980(96)00098-6\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Prostaglandins\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0090698096000986\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0090698096000986","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Altered prostanoid production by cumulus-oocyte complexes in a rat model of non-insulin-dependent diabetes mellitus
Ovulation, oocyte maturation and PGE and PGF2α production by oocyte-cumulus complexes were evaluated in rats with non-insulin-dependent diabetes induced by neonatal streptozotocin. Diabetic rats had normal estrous cycles, but ovulated a lower number of oocytes at estrus. When oocytes from control and diabetic rats obtained at proestrus were matured “in vitro” during 1, 2 or 4 hours (hr) of culture, differences were not found in the percent of germinal vesicle breakdown between both experimental groups. PGE and PGF2α accumulation was higher in ovulated oocyte-cumulus complexes when compared to immature or “in vitro”-matured oocyte-cumulus complexes in both normal and diabetic rats. When control and diabetic rats are compared, more PGE and PGF2α accumulation was observed in immature, “in vitro”-matured and in ovulated oocytecumulus complexes.
A lower number of oocytes ovulated and increased oocyte-cumulus complexes prostaglandin production has been observed in this mildly diabetic experimental model. These abnormalities are similar to those previously found when 10 day embryos were evaluated in noninsulin-dependent diabetic rats.
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