Pharmacokinetics of antipyrine in calves at neonatal period fed with casein supplemented food.

The purpose of the studies was to evaluate (on the basis of pharmacokinetics of antipyrine) hepatic biotransformation rate in calves in neonatal period, which received supplementary casein dose in their food. It was found that 25% increase in protein content in food ration of the examined animals significantly increased hepatic biotransformation rate (activity of monooxygenases dependent on cytochrome P-450). The results obtained also indicate that a protein-rich diet may significantly increase metabolism of other xenobiotics in MFO-P-450 enzymatic system, provided that they undergo the same biotransformation process as antipyrine.