In-line filtration of SAG-M red cell concentrates prepared in top/bottom or conventional bag systems.

SAG-M RCCs were prepared in triple conventional or quadruple top/bottom bag systems and filtered at +4 degrees C using the in-line filter system Leucoflex LCR 4 Macopharma after 16-24-30 h of storage. Postfiltration WBC content was determined by Nageotte hemocytometer counting. The mean WBC content of the units prepared in conventional bag systems and filtered was higher than that of the units prepared in T/B bag systems. The best results could be obtained in T/B RCCs stored for 24 h; potassium and hemolysis levels were also improved. The Leucoflex LCR 4 in-line filter T/B system can be recommended for application in the clinical routine by virtue of the effective leukocyte elimination.