抗细胞间粘附分子-1和抗淋巴细胞功能相关抗原-1单克隆抗体对小鼠肿瘤转移的影响。

Invasion & metastasis Pub Date : 1996-01-01
R Sun, H Hojo, K Kato, Y Hashimoto
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引用次数: 0

摘要

通过小鼠注射抗细胞间粘附分子-1 (anti-ICAM-1)和抗淋巴细胞功能相关抗原-1 (anti-LFA-1)单克隆抗体(mab),研究其对肿瘤转移的影响。根据剂量的不同,抗ICAM-1单抗(KAT-1)对ICAM-1 + LFA-1 + P815肥大细胞瘤细胞的肝转移表现出抑制和促进作用,而在任何剂量下,它都能增强ICAM-1-LFA-1- meth - a纤维肉瘤细胞的肺转移。相比之下,抗lfa -1 mAb (KBA)仅对两种肿瘤系的转移有促进作用。单抗治疗小鼠脾脏P815肥大细胞瘤细胞的转移增强。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of anti-intercellular adhesion molecule-1 and anti-lymphocyte-function-associated antigen-1 monoclonal antibodies on the metastasis of murine tumors.

Anti-intercellular adhesion molecule-1 (anti-ICAM-1) and anti-lymphocyte-function-associated antigen-1 (anti-LFA-1) monoclonal antibodies (mAbs) were injected into mice and their effects on tumor metastasis were investigated using two murine models. Depending on the dose, the anti-ICAM-1 mAb (KAT-1) expressed both inhibitory and promoting effects on liver metastases of ICAM-1 + LFA-1 + P815 mastocytoma cells, whereas it enhanced lung metastases of the ICAM-1-LFA-1-Meth-A fibrosarcoma cells at any doses. In contrast, anti-LFA-1 mAb (KBA) showed promoting effects only on the metastases of both tumor lines. Treatment of mice with either mAb enhanced metastases of P815 mastocytoma cells in the spleen.

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