利坦色林诱导大鼠睡眠-觉醒阶段的改变。

R Kirov, S Moyanova
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引用次数: 0

摘要

10只雄性Wistar大鼠长期植入常规电极用于睡眠-觉醒阶段检测。分别于5-羟色胺-2 (5-HT2)拮抗剂利坦色林两剂(0.63 mg/kg和2.5 mg/kg)和利坦色林载药后,每周进行3次12小时脑电图(EEG)记录。本研究的目的是检验利坦色林对睡眠-清醒阶段的影响,并获得有关5-HT2受体参与调节睡眠和清醒行为的额外数据。睡眠-觉醒阶段共分为六个阶段:主动醒着、安静醒着、轻度慢波睡眠、深度慢波睡眠、中间睡眠阶段和矛盾睡眠。将用药后12 h的脑电图记录分为连续3个4 h时段,并对整个用药后每分钟的睡眠-清醒阶段进行视觉评分。为了评价利坦色林在动力学上的作用,对三个周期进行了比较。研究结果显示,醒觉和矛盾睡眠显著减少,慢波睡眠(主要是深慢波睡眠)和睡眠中间阶段显著增加。这些睡眠-清醒阶段的变化是以剂量依赖的方式发生的,利坦色林的剂量越大,利坦色林的效果越强。这种变化在头4个小时内更为明显,然后在睡眠-清醒阶段出现恢复,除了矛盾睡眠。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ritanserin-induced changes in sleep-waking phases in rats.

Ten male Wistar rats were chronically implanted with conventional electrodes for sleep-waking stages detection. Three 12-hour electroencephalographic (EEG) registrations were performed once a week, after i.p. injection of the serotonin-2 (5-HT2) antagonist ritanserin at two doses (0.63 mg/kg and 2.5 mg/kg) and after ritanserin vehicle. The goal of the present study was to examine the effects of ritanserin on sleep-waking phases, and to obtain additional data about the participation of 5-HT2 receptors in the regulation of sleep and wake behaviour. Six sleep-waking stages were detected: active waking, quiet waking, light slow-wave sleep, deep slow-wave sleep, intermediate stage of sleep and paradoxical sleep. Each of the 12-h postdrug EEG records was divided into 3 consecutive 4-hour periods and the sleep-waking stages were scored visually for every minute of the whole postdrug period. The three periods were compared in order to evaluate the effect of ritanserin in dynamics. The results obtained showed a significant decrease in wakefulness and paradoxical sleep, a significant increase in slow-wave sleep (mainly the deep slow-wave sleep) and in the intermediate stage of sleep. These changes in the sleep-waking phases occurred in a dose-dependent manner, the larger the dose of ritanserin, the stronger the effect of ritanserin. The changes were more pronounced during the first 4-h period and then a restoration in the sleep-waking phases took place except for the paradoxical sleep.

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